From Denver:  Take I-25 North almost to Wheatland, Wy, take WY-34 W (Laramie Exit 73) and drive about 24.5 miles, turn left on Sybille Rd/County Rd 12, drive about  8.6 miles on dirt road and turn left under the overhead sign that reads “Timber Canyon Ranch”, a couple more miles and you will quickly find the ranch headquarters.

Keep in mind that the ranch is 45 miles from any town so make sure you stop in Cheyenne for gas and any last minute things that you may need.